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Prediction of prostate cancer Gleason score upgrading from biopsy to radical prostatectomy using pre-biopsy multiparametric MRI PIRADS scoring system.
- Source :
-
Scientific reports [Sci Rep] 2020 May 07; Vol. 10 (1), pp. 7722. Date of Electronic Publication: 2020 May 07. - Publication Year :
- 2020
-
Abstract
- An increase or 'upgrade' in Gleason Score (GS) in prostate cancer following Transrectal Ultrasound (TRUS) guided biopsies remains a significant challenge to overcome. to evaluate whether MRI has the potential to narrow the discrepancy of histopathological grades between biopsy and radical prostatectomy, three hundred and thirty men treated consecutively by laparoscopic radical prostatectomy (LRP) between July 2014 and January 2019 with localized prostate cancer were included in this study. Independent radiologists and pathologists assessed the MRI and histopathology of the biopsies and prostatectomy specimens respectively. A multivariate model was constructed using logistic regression analysis to assess the ability of MRI to predict upgrading in biopsy GS in a nomogram. A decision-analysis curve was constructed assessing impact of nomogram using different thresholds for probabilities of upgrading. PIRADS scores were obtained from MRI scans in all the included cases. In a multivariate analysis, the PIRADS v2.0 score significantly improved prediction ability of MRI scans for upgrading of biopsy GS (pā=ā0.001, 95% CI [0.06-0.034]), which improved the C-index of predictive nomogram significantly (0.90 vs. 0.64, pā<ā0.05). PIRADS v2.0 score was an independent predictor of postoperative GS upgrading and this should be taken into consideration while offering treatment options to men with localized prostate cancer.
- Subjects :
- Adult
Aged
Biopsy
Humans
Image-Guided Biopsy
Laparoscopy methods
Male
Middle Aged
Neoplasm Grading
Nomograms
Postoperative Period
Prognosis
Prostate diagnostic imaging
Prostate pathology
Prostate surgery
Prostatic Neoplasms pathology
Retrospective Studies
Ultrasound, High-Intensity Focused, Transrectal methods
Magnetic Resonance Imaging methods
Prostatectomy
Prostatic Neoplasms diagnostic imaging
Prostatic Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32382097
- Full Text :
- https://doi.org/10.1038/s41598-020-64693-y