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[Identification and Analysis of LSD Derivatives in Illegal Products as Paper Sheet].
- Source :
-
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan [Yakugaku Zasshi] 2020; Vol. 140 (5), pp. 739-750. - Publication Year :
- 2020
-
Abstract
- To prevent the abuse of new psychoactive substances (NPS), a total of 2372 substances and two plants are controlled as "Designated Substances" in Japan as of September 2019. Although the distribution of these substances has decreased for the past three years, newly-emerged NPS are still being found. In this study, we detected four lysergic acid diethylamide (LSD) derivatives as designer drugs from four paper sheet products, which were obtained from 2014 to 2017 in Japan. The compounds were identified as 4-Acetyl-N,N-diethyl-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (ALD-52), N,N,7-triethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (ETH-LAD), 7-Allyl-N,N-diethyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (AL-LAD), N,N-diethyl-7-methyl-4-propionyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (1P-LSD), by GC-MS, LC-MS, LC-Q-TOF-MS and NMR analyses. Further, we studied the extraction methods of LSD derivatives from paper sheet, and the analytical conditions of GC-MS, LC-MS and LC-FL(fluorescence). Among LSD derivatives, 1P-LSD have been controlled as designated substances (Shitei Yakubutsu) under the Pharmaceutical and Medical Device Act in Japan since April 2016. For the legislation of the other derivatives identified in this study, the evaluation of their pharmacological properties are now in progress.
- Subjects :
- Chromatography, Liquid methods
Gas Chromatography-Mass Spectrometry methods
Lysergic Acid Diethylamide analogs & derivatives
Lysergic Acid Diethylamide chemistry
Magnetic Resonance Spectroscopy methods
Mass Spectrometry methods
Spectrometry, Fluorescence methods
Designer Drugs analysis
Illicit Drugs analysis
Lysergic Acid Diethylamide analysis
Paper
Subjects
Details
- Language :
- Japanese
- ISSN :
- 1347-5231
- Volume :
- 140
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
- Publication Type :
- Academic Journal
- Accession number :
- 32378678
- Full Text :
- https://doi.org/10.1248/yakushi.19-00230