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An immunofluorescent study of basement membranes in squamous cell carcinoma of the cervix, vagina, and vulva.

Authors :
Pertschuk LP
Boyce JG
Urcuyo R
Source :
Obstetrics and gynecology [Obstet Gynecol] 1977 Apr; Vol. 49 (4), pp. 417-20.
Publication Year :
1977

Abstract

Basement membranes of 33 samples of in situ or invasive squamous cell carcinomas of the cervix uteri, vagina, and vulva were studied by defined immunofluorescence technics. Pooled serum from patients with bullous pemphigoid, containing specific antibody to squamous epithelial basement membrane, was utilized. Essentially normal basement membranes were found in all cases of in situ carcinoma and in 18 cases of invasive carcinoma. Basement membranes appeared poorly formed in three specimens with invasion and were absent in the remaining three. These findings support the premise that penetration of the basement membrane is not a valid criterion for distinguishing in situ from invasive squamous cell carcinoma.

Details

Language :
English
ISSN :
0029-7844
Volume :
49
Issue :
4
Database :
MEDLINE
Journal :
Obstetrics and gynecology
Publication Type :
Academic Journal
Accession number :
323765