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18 F-Sodium Fluoride ( 18 F-NaF) for Imaging Microcalcification Activity in the Cardiovascular System.
- Source :
-
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Jul; Vol. 40 (7), pp. 1620-1626. Date of Electronic Publication: 2020 May 07. - Publication Year :
- 2020
-
Abstract
- Accumulating preclinical and clinical evidence suggests that calcification is one of the body's primary responses to injury and a key pathological feature of cardiovascular disease. Calcification activity can now be imaged using <superscript>18</superscript> F-sodium fluoride ( <superscript>18</superscript> F-NaF) positron emission tomography (PET) in combination with either computed tomography or magnetic resonance. These techniques allow visualization of calcification activity and, therefore, provide different information to the established macroscopic calcium imaged with computed tomography. Indeed, <superscript>18</superscript> F-NaF PET has been used to investigate a wide range of valvular conditions, including aortic stenosis, mitral annular calcification, and bioprosthetic valve disease, as well as vascular conditions, including abdominal aortic aneurysm disease, coronary, and carotid atherosclerosis, peripheral vascular disease, and erectile dysfunction. In this brief review, we will focus on how <superscript>18</superscript> F-NaF PET has improved our pathophysiological understanding of cardiovascular calcification and how it can be used as a marker of vascular calcification, providing a useful tool that can be utilized in clinical trials investigating the prediction of both disease progression and clinical events. Finally, we will discuss how <superscript>18</superscript> F-NaF might be employed clinically to improve patient assessment and to guide decision-making.
- Subjects :
- Animals
Calcinosis therapy
Female
Heart Valve Diseases therapy
Humans
Impotence, Vasculogenic therapy
Male
Predictive Value of Tests
Prognosis
Vascular Calcification therapy
Calcinosis diagnostic imaging
Fluorine Radioisotopes administration & dosage
Heart Valve Diseases diagnostic imaging
Impotence, Vasculogenic diagnostic imaging
Positron-Emission Tomography
Radiopharmaceuticals administration & dosage
Sodium Fluoride administration & dosage
Vascular Calcification diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4636
- Volume :
- 40
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Arteriosclerosis, thrombosis, and vascular biology
- Publication Type :
- Academic Journal
- Accession number :
- 32375543
- Full Text :
- https://doi.org/10.1161/ATVBAHA.120.313785