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Sex-specific pattern of left ventricular hypertrophy and diastolic function in patients with type 2 diabetes mellitus.
- Source :
-
European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2021 Jul 20; Vol. 22 (8), pp. 930-940. - Publication Year :
- 2021
-
Abstract
- Aims: Few prospective studies have evaluated sex-specific pattern, natural progression of left ventricular (LV) remodelling, and diastolic dysfunction in patients with type 2 diabetes (T2DM). The aim of this study was to study the sex-specific prevalence, longitudinal changes of LV remodelling, and diastolic dysfunction in patients with T2DM. Further, the prognostic value of diastolic function in women and men was also evaluated.<br />Methods and Results: A total of 350 patients with T2DM (mean age 61 ± 11 years; women, 48.3%) was recruited. Detailed echocardiography was performed at baseline and after 25 months. A major adverse cardiovascular event (MACE) was defined as cardiovascular death, heart failure hospitalization, or myocardial infarction. Despite a similar age, prevalence of hypertension and body mass index, women had a higher prevalence of LV hypertrophy and diastolic dysfunction at baseline and follow-up compared with men. A total of 21 patients developed MACE (5 cardiovascular death, 9 hospitalization for heart failure, and 7 myocardial infarction) during a median follow-up of 56 months. Women with diastolic dysfunction had a higher incidence of MACE than those with normal diastolic function but this association was neutral in men. Multivariable Cox-regression analysis indicated that diastolic dysfunction was associated with MACE in women [hazard ratio = 6.30; 95% confidence interval (CI) = 1.06-37.54; P < 0.05] but not men (hazard ratio = 2.29, 95% CI = 0.67-7.89; P = 0.19).<br />Conclusion: LV hypertrophy and diastolic dysfunction, both at baseline and follow-up, were more common in women than men. Pre-clinical diastolic dysfunction was independently associated with MACE only in women with T2DM but was neutral in men.<br /> (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Aged
Female
Humans
Hypertrophy, Left Ventricular diagnostic imaging
Hypertrophy, Left Ventricular epidemiology
Male
Middle Aged
Prognosis
Prospective Studies
Risk Factors
Ventricular Function, Left
Diabetes Mellitus, Type 2 epidemiology
Ventricular Dysfunction, Left diagnostic imaging
Ventricular Dysfunction, Left epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2047-2412
- Volume :
- 22
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European heart journal. Cardiovascular Imaging
- Publication Type :
- Academic Journal
- Accession number :
- 32372092
- Full Text :
- https://doi.org/10.1093/ehjci/jeaa079