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Quantitative Assessment of Arthritis Activity in Rheumatoid Arthritis Patients Using [ 11 C]DPA-713 Positron Emission Tomography.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Apr 29; Vol. 21 (9). Date of Electronic Publication: 2020 Apr 29. - Publication Year :
- 2020
-
Abstract
- Treatment for rheumatoid arthritis (RA) should be started as early as possible to prevent destruction of bone and cartilage in affected joints. A new diagnostic tool for both early diagnosis and therapy monitoring would be valuable to reduce permanent joint damage. Positron emission tomography (PET) imaging of macrophages is a previously demonstrated non-invasive means to visualize (sub)clinical arthritis in RA patients. We developed a kinetic model to quantify uptake of the macrophage tracer [ <superscript>11</superscript> C]DPA-713 ( N , N -diethyl-2-[2-(4-methoxyphenyl)-5,7-dimethylpyrazolo [1,5-a]pyrimidin-3-yl]acetamide) in arthritic joints of RA patients and to assess the performance of several simplified methods. Dynamic [ <superscript>11</superscript> C]DPA-713 scans of 60 min with both arterial and venous blood sampling were performed in five patients with clinically active disease. [ <superscript>11</superscript> C]DPA-713 showed enhanced uptake in affected joints of RA patients, with tracer uptake levels corresponding to clinical presence and severity of arthritis. The optimal quantitative model for assessment of [ <superscript>11</superscript> C]DPA-713 uptake was the irreversible two tissue compartment model (2T3k). Both K <subscript>i</subscript> and standardized uptake value (SUV) correlated with the presence of arthritis in RA patients. Using SUV as an outcome measure allows for a simplified static imaging protocol that can be used in larger cohorts.
- Subjects :
- Arthritis, Rheumatoid metabolism
Biomarkers
Female
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Severity of Illness Index
Acetamides chemistry
Arthritis, Rheumatoid diagnosis
Carbon Radioisotopes
Positron-Emission Tomography methods
Pyrazoles chemistry
Pyrimidines chemistry
Radiopharmaceuticals
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 32365551
- Full Text :
- https://doi.org/10.3390/ijms21093137