Association of Interleukin-4 Polymorphisms With Breast Cancer in Taiwan.

Authors :: Chu CN
Wang YC
Chang WS
Wang ZH
Liu LC
Wang SC
Lin CC
Liu TY
Chang JG
Tsai CW
Yu CC
Bau DT
Source :: In vivo (Athens, Greece) [In Vivo] 2020 May-Jun; Vol. 34 (3), pp. 1111-1116.
Publication Year :: 2020
Abstract: Background/aim: The present study aimed at evaluating the contribution of IL-4 promoter T-1099G (rs2243248), C-589T (rs2243250), C-33T (rs2070874) genotypes to the risk of breast cancer in Taiwanese.<br />Materials and Methods: A total of 1232 breast cancer patients and 1232 age-matched controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.<br />Results: Genotypic frequencies of IL-4 rs2243248, rs2243250 and rs2070874 were not differentially distributed between case and control groups. Consistently, there was no difference in the distribution of allelic frequencies among patients and controls.<br />Conclusion: IL-4 rs2243248, rs2243250 and rs2070874 do not confer breast cancer susceptibility in Taiwanese.<br /> (Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)