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First-line endocrine therapy for advanced breast cancer. A real-world study at a Latin American university health institution.
- Source :
-
Current medical research and opinion [Curr Med Res Opin] 2020 Jul; Vol. 36 (7), pp. 1195-1199. Date of Electronic Publication: 2020 May 14. - Publication Year :
- 2020
-
Abstract
- Objective: Clinical guidelines recommend the use of endocrine therapy (ET) in advanced hormone receptor positive (HR+) human epidermal growth factor receptor type 2 negative (HER2-) breast cancer (BC) patients in the absence of visceral disease or ET resistance. Furthermore, studies indicate similar response and survival rates using ET or cytotoxic chemotherapy (CT). Methods: Herein, we assessed clinical characteristics, type of systemic therapy and survival rates of advanced HR + HER2-BC patients in our database. Results: A total of 172 advanced HR + HER2-BC patients were treated at our institution between 1997 and 2019. Sixty percent received first-line ET (4% received combined ET). Median age of this subset was 55 years (range: 30-86). Similarly, the median age of patients that received CT was 54 years (range: 21-83). Over time, 30% of patients received ET in the 2000-2005 period; this increased to 70% in the 2016-2019 period ( p = .045). Overall survival (OS) was 97 months and 51 months for patients treated with ET or CT, respectively ( p = .002). Conclusions: To the best of our knowledge this is the first study assessing the use of ET in Chilean advanced HR + HER2-BC patients. Several patients in our institution receive CT without indication. The increase in ET usage over time can be attributed to better and faster immunohistochemical detection methods for Estrogen Receptor (ER), changes in educational and government policies, and a wider variety of ET options. Finally, clinical trials have failed to demonstrate a substantial benefit of CT over ET in this setting.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Breast Neoplasms chemistry
Breast Neoplasms mortality
Female
Humans
Middle Aged
Receptor, ErbB-2 analysis
Receptors, Estrogen metabolism
Receptors, Progesterone metabolism
Retrospective Studies
Young Adult
Antineoplastic Agents, Hormonal therapeutic use
Breast Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1473-4877
- Volume :
- 36
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Current medical research and opinion
- Publication Type :
- Academic Journal
- Accession number :
- 32351137
- Full Text :
- https://doi.org/10.1080/03007995.2020.1763282