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IGF-1C domain-modified chitosan hydrogel accelerates cutaneous wound healing by promoting angiogenesis.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2020 Jul; Vol. 12 (13), pp. 1239-1251. Date of Electronic Publication: 2020 Apr 30. - Publication Year :
- 2020
-
Abstract
- Background: Complete regeneration after skin injury remains a critical clinical challenge. Hydrogels, modified with growth factors or mimicking peptides, have been applied for functional tissue regeneration by increasing the bioactivity of engineered matrices. Methodology & results:  We synthesized an injectable biological hydrogel, C domain of IGF-1 (IGF-1C)-modified chitosan (CS-IGF-1C) hydrogel. Mouse model of cutaneous wound healing was established to investigate whether this hydrogel could promote wound healing. Our results demonstrated that CS-IGF-1C hydrogel exhibited superior proangiogenic effects, resulting in accelerated wound closure and improved extracellular matrix remodeling. Bioluminescence imaging and histology analysis confirmed the proangiogenic role of CS-IGF-1C hydrogel. Conclusion: CS-IGF-1C hydrogel could accelerate cutaneous wound healing by stimulating angiogenesis.
- Subjects :
- Animals
Carbohydrate Conformation
Cell Proliferation drug effects
Cells, Cultured
Chitosan chemistry
Disease Models, Animal
Human Umbilical Vein Endothelial Cells drug effects
Humans
Hydrogels chemical synthesis
Hydrogels chemistry
Insulin-Like Growth Factor I chemistry
Mice
Mice, Transgenic
Neovascularization, Pathologic pathology
Chitosan pharmacology
Hydrogels pharmacology
Insulin-Like Growth Factor I pharmacology
Neovascularization, Pathologic drug therapy
Wound Healing drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 12
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32351127
- Full Text :
- https://doi.org/10.4155/fmc-2020-0071