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Evaluation of adipokines, adiponectin, visfatin, and omentin, in uncomplicated type I diabetes patients before and after treatment of diabetic ketoacidosis.
- Source :
-
Journal of endocrinological investigation [J Endocrinol Invest] 2020 Dec; Vol. 43 (12), pp. 1723-1727. Date of Electronic Publication: 2020 Apr 27. - Publication Year :
- 2020
-
Abstract
- Background: Diabetic ketoacidosis (DKA) is potentially a lethal complication of uncontrolled, especially type 1, diabetes. Understanding the mechanisms underlying adipokine involvement in the regulation of glucose metabolism is important to prevent complications of hyperglycemia. The role of novel adipokines during DKA in human remains unclear.<br />Method: The method is to determine the changes in the circulating levels of adiponectin, visfatin, and omentin after treating DKA in the patients referred to Shohadaye Khalij-e-Fars hospital at the Bushehr University of Medical Sciences. Measuring adipokines (adiponectin, visfatin, and omentin) in 31 patients with DKA who are admitted in Shohadaye Khalij-e-Fars hospital at the Bushehr University of Medical Sciences. Adipokines are measured at the time of admission and after recovery from DKA, using ELISA method.<br />Results: After recovery from DKA, omentin-1 serum concentration decreased significantly (from 183 to 165), but adiponectin and visfatin did not change significantly.<br />Conclusion: Omentin-1 may play a significant role in insulin resistance during the DKA and could be potentially recommended as a marker of recovery in DKA.
- Subjects :
- Adiponectin blood
Adolescent
Adult
Cohort Studies
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 therapy
Diabetic Ketoacidosis etiology
Diabetic Ketoacidosis therapy
Female
GPI-Linked Proteins blood
Humans
Iran
Male
Middle Aged
Prospective Studies
Time Factors
Young Adult
Adipokines blood
Cytokines blood
Diabetes Mellitus, Type 1 blood
Diabetic Ketoacidosis blood
Lectins blood
Nicotinamide Phosphoribosyltransferase blood
Subjects
Details
- Language :
- English
- ISSN :
- 1720-8386
- Volume :
- 43
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of endocrinological investigation
- Publication Type :
- Academic Journal
- Accession number :
- 32342445
- Full Text :
- https://doi.org/10.1007/s40618-020-01259-9