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Gonad differentiation toward ovary.
- Source :
-
Annales d'endocrinologie [Ann Endocrinol (Paris)] 2020 Jun; Vol. 81 (2-3), pp. 83-88. Date of Electronic Publication: 2020 Apr 15. - Publication Year :
- 2020
-
Abstract
- Gonad differentiation depends on a set of cellular and hormonal signals interacting in a specific order, with very precise windows of action, to contribute to the establishment of the genital tract and a male or female phenotype. Research initially focused on the stages of gonad differentiation toward testis, in particular following the identification in 1990 of the SRY factor on chromosome Y. The mechanisms involved in gonad differentiation toward ovary took longer to identify. Thanks to patients with different sexual development (DSD) and animal knock-out models, description of the cascades involved in the activation and maintenance of ovarian development has progressed considerably in recent years.<br /> (Copyright © 2020 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Animals
Cell Differentiation genetics
Female
Gene Expression Regulation, Developmental
Gonads embryology
Gonads growth & development
Humans
Male
Ovary embryology
Ovary growth & development
Phenotype
Sexual Development genetics
Sexual Development physiology
Gonads physiology
Ovary physiology
Sex Determination Processes physiology
Sex Differentiation genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2213-3941
- Volume :
- 81
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Annales d'endocrinologie
- Publication Type :
- Academic Journal
- Accession number :
- 32340851
- Full Text :
- https://doi.org/10.1016/j.ando.2020.04.004