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METTL3 regulates the malignancy of cervical cancer via post-transcriptional regulation of RAB2B.
- Source :
-
European journal of pharmacology [Eur J Pharmacol] 2020 Jul 15; Vol. 879, pp. 173134. Date of Electronic Publication: 2020 Apr 24. - Publication Year :
- 2020
-
Abstract
- Cervical cancer is one of the leading causes of cancer death in women worldwide. While molecular mechanisms of initiation and cervical carcinogenesis are not well studied. Our data showed that the expression of Methyltransferase-like 3 (METTL3) was upregulated in cervical tumor tissues as compared with normal tissues. Its expression was associated with poor prognosis of cervical cancer. Knockdown of METTL3 can suppress the proliferation of cervical cancer cells. The expression of METTL3 was significantly correlated with the expression of RAB2B, one member of RAS oncogene family. Over expression of RAB2B can significantly attenuate sh-METTL3-suppressed cell proliferation. Mechanistically, METTL3 can increase the mRNA stability of RAB2B via an IGF2BP3-dependent manner. Collectively, METTL3 can trigger growth of cervical cancer cells via upregulation of RAB2B. It indicated that METTL3 might be a potential target for cervical cancer therapy.<br />Competing Interests: Declaration of competing interest The authors declare no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Cell Proliferation
Cervix Uteri metabolism
Female
Gene Expression Regulation, Neoplastic
Humans
Methyltransferases genetics
Prognosis
RNA-Binding Proteins genetics
Up-Regulation
Uterine Cervical Neoplasms genetics
rab2 GTP-Binding Protein genetics
rab2 GTP-Binding Protein metabolism
Methyltransferases metabolism
Uterine Cervical Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0712
- Volume :
- 879
- Database :
- MEDLINE
- Journal :
- European journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 32339511
- Full Text :
- https://doi.org/10.1016/j.ejphar.2020.173134