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Prolyl hydroxylase inhibitors: a breath of fresh air for diabetic kidney disease?
- Source :
-
Kidney international [Kidney Int] 2020 May; Vol. 97 (5), pp. 855-857. - Publication Year :
- 2020
-
Abstract
- Diabetes affects oxygen availability in the kidney, forcing the renal environment to rapidly and sustainably adapt. Physiological adaptations including activation of hypoxia inducible factor-1α and metabolic reprogramming toward pathways requiring less oxygen to maintain adenosine triphosphate production such as anaerobic glycolysis are impaired in the diabetic kidney. However, this study by Hasegawa et al. demonstrates renoprotection in diabetic kidney disease via the use of the hypoxia inducible factor-1α stabilizer enarodustat, opening a new therapeutic avenue to tackle these metabolic abnormalities.<br /> (Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 97
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 32331596
- Full Text :
- https://doi.org/10.1016/j.kint.2020.01.038