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Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis.
Rebaudioside affords hepatoprotection ameliorating sugar sweetened beverage- induced nonalcoholic steatohepatitis.
- Source :
-
Scientific reports [Sci Rep] 2020 Apr 21; Vol. 10 (1), pp. 6689. Date of Electronic Publication: 2020 Apr 21. - Publication Year :
- 2020
-
Abstract
- Sugar-sweetened beverage consumption is a known independent risk factor for nonalcoholic steatohepatitis (NASH). Non-caloric sweeteners (NCS) are food additives providing sweetness without calories and are considered safe and/or not metabolized by the liver. The potential role of newer NCS in the regulation of NASH, however, remain unknown. Our study aimed to determine the impact of newer NCS including Rebaudioside A and sucralose on NASH using high fat diet induced obesity mouse model by substituting fructose and sucrose with NCS in the drinking water. We characterized the phenotype of NCS- treated obesity and investigated the alterations of hepatic function and underlying mechanisms. We found that NCS have no impact on weight gain and energy balance in high fat diet induced obesity. However, in comparison to fructose and sucrose, Rebaudioside A significantly improved liver enzymes, hepatic steatosis and hepatic fibrosis. Additionally, Rebaudioside A improved endoplasmic reticulum (ER) stress related gene expressions, fasting glucose levels, insulin sensitivity and restored pancreatic islet cell mass, neuronal innervation and microbiome composition. We concluded that Rebaudioside A significantly ameliorated murine NASH, while the underlying mechanisms requires further investigation.
- Subjects :
- Adiposity drug effects
Animals
Diet, High-Fat
Diterpenes, Kaurane pharmacology
Endoplasmic Reticulum Stress drug effects
Energy Metabolism drug effects
Fructose
Glucose metabolism
Homeostasis drug effects
Insulin Resistance
Insulin-Secreting Cells drug effects
Insulin-Secreting Cells pathology
Liver drug effects
Liver physiopathology
Mice
Microbiota drug effects
Obesity etiology
Obesity metabolism
Protective Agents pharmacology
Weight Gain drug effects
Diterpenes, Kaurane therapeutic use
Liver pathology
Non-alcoholic Fatty Liver Disease chemically induced
Non-alcoholic Fatty Liver Disease drug therapy
Protective Agents therapeutic use
Sugar-Sweetened Beverages adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 32317687
- Full Text :
- https://doi.org/10.1038/s41598-020-63688-z