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Spectrum of anti-myelin oligodendrocyte glycoprotein antibody (MOG-Ab)-associated diseases: an Indian perspective.
- Source :
-
Acta neurologica Belgica [Acta Neurol Belg] 2021 Aug; Vol. 121 (4), pp. 927-931. Date of Electronic Publication: 2020 Apr 20. - Publication Year :
- 2021
-
Abstract
- Myelin oligodendrocyte glycoprotein antibody (MOG-Ab) is involved in the pathogenesis of central nervous system (CNS) demyelination disorders. We aimed to explore the spectrum of MOG-Ab-associated diseases in eastern India. A single-center, prospective observational study was done over a period of 2 years in a tertiary care hospital of eastern India. Patients with CNS demyelination disorders who tested positive for MOG-Ab using live cell-based assay were included in the study; while, those with age less than 1 year, documented preexisting CNS structural lesions, developmental delays or diagnosed multiple sclerosis were excluded. Demographic profile, clinical spectrum, disease course, radiological features as well as response to treatment were analyzed among included patients. Twenty MOG-Ab-positive patients were included (M:F 1:1.85). The median age of symptom onset was 10.5 years. The median follow-up of patients was 13 months. Acute disseminated encephalomyelitis (ADEM) was the commonest presentation at first attack (55%), followed by optic neuritis (ON) (45%). Patients with ADEM had a significantly lower age at first attack (p = 0.025). Monophasic and relapsing disease courses were seen in 45% and 55% patients, respectively. While all patients with only ADEM had a monophasic course, 77.8% with ON had a relapsing course. Among patients who presented with isolated transverse myelitis, 75% had a monophasic course and all had disease confined to the spinal cord. Good response to corticosteroids was seen in majority of participants. Second-line drugs were needed in 55% patients, rituximab being the commonest second-line agent used. 35% patients had significant disability (EDSS > 4) at last follow-up. MOG-Ab-associated diseases have diverse clinical phenotypes characterized by age-dependent pattern-specific courses.<br /> (© 2020. Belgian Neurological Society.)
- Subjects :
- Adolescent
Adult
Child
Encephalomyelitis, Acute Disseminated diagnostic imaging
Encephalomyelitis, Acute Disseminated epidemiology
Female
Follow-Up Studies
Humans
India epidemiology
Male
Myelitis, Transverse diagnostic imaging
Myelitis, Transverse epidemiology
Optic Neuritis diagnostic imaging
Optic Neuritis epidemiology
Prospective Studies
Young Adult
Autoantibodies blood
Encephalomyelitis, Acute Disseminated blood
Myelin-Oligodendrocyte Glycoprotein blood
Myelitis, Transverse blood
Optic Neuritis blood
Subjects
Details
- Language :
- English
- ISSN :
- 2240-2993
- Volume :
- 121
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Acta neurologica Belgica
- Publication Type :
- Academic Journal
- Accession number :
- 32314270
- Full Text :
- https://doi.org/10.1007/s13760-020-01356-9