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Transformable hybrid semiconducting polymer nanozyme for second near-infrared photothermal ferrotherapy.
- Source :
-
Nature communications [Nat Commun] 2020 Apr 20; Vol. 11 (1), pp. 1857. Date of Electronic Publication: 2020 Apr 20. - Publication Year :
- 2020
-
Abstract
- Despite its growing promise in cancer treatment, ferrotherapy has low therapeutic efficacy due to compromised Fenton catalytic efficiency in tumor milieu. We herein report a hybrid semiconducting nanozyme (HSN) with high photothermal conversion efficiency for photoacoustic (PA) imaging-guided second near-infrared photothermal ferrotherapy. HSN comprises an amphiphilic semiconducting polymer as photothermal converter, PA emitter and iron-chelating Fenton catalyst. Upon photoirradiation, HSN generates heat not only to induce cytotoxicity but also to enhance Fenton reaction. The increased ·OH generation promotes both ferroptosis and apoptosis, oxidizes HSN (42 nm) and transforms it into tiny segments (1.7 nm) with elevated intratumoral permeability. The non-invasive seamless synergism leads to amplified therapeutic effects including a deep ablation depth (9 mm), reduced expression of metastasis-related proteins and inhibition of metastasis from primary tumor to distant organs. Thereby, our study provides a generalized nanozyme strategy to compensate both ferrotherapy and phototherapeutics for complete tumor regression.
- Subjects :
- Animals
Apoptosis
Catalysis
Cell Line, Tumor
Chelating Agents
Ferroptosis
HeLa Cells
Humans
Hydrogen Peroxide
Liver Neoplasms pathology
Lung Neoplasms pathology
Mice
Microscopy, Confocal
NIH 3T3 Cells
Nanomedicine methods
Nanoparticles chemistry
Neoplasm Metastasis
Neoplasms metabolism
Oxygen chemistry
Photoacoustic Techniques
Rats
Reactive Oxygen Species metabolism
Iron therapeutic use
Neoplasms pathology
Neoplasms therapy
Phototherapy methods
Polymers chemistry
Semiconductors
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 32312987
- Full Text :
- https://doi.org/10.1038/s41467-020-15730-x