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Scavenger receptor-A is a biomarker and effector of rheumatoid arthritis: A large-scale multicenter study.
- Source :
-
Nature communications [Nat Commun] 2020 Apr 20; Vol. 11 (1), pp. 1911. Date of Electronic Publication: 2020 Apr 20. - Publication Year :
- 2020
-
Abstract
- Early diagnosis is critical to improve outcomes in rheumatoid arthritis (RA), but current diagnostic tools have limited sensitivity. Here we report a large-scale multicenter study involving training and validation cohorts of 3,262 participants. We show that serum levels of soluble scavenger receptor-A (sSR-A) are increased in patients with RA and correlate positively with clinical and immunological features of the disease. This discriminatory capacity of sSR-A is clinically valuable and complements the diagnosis for early stage and seronegative RA. sSR-A also has 15.97% prevalence in undifferentiated arthritis patients. Furthermore, administration of SR-A accelerates the onset of experimental arthritis in mice, whereas inhibition of SR-A ameliorates the disease pathogenesis. Together, these data identify sSR-A as a potential biomarker in diagnosis of RA, and targeting SR-A might be a therapeutic strategy.
- Subjects :
- Animals
Arthritis, Rheumatoid pathology
Disease Models, Animal
Humans
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Rheumatoid Factor
Scavenger Receptors, Class A genetics
Sensitivity and Specificity
Arthritis, Rheumatoid diagnosis
Arthritis, Rheumatoid metabolism
Biomarkers
Scavenger Receptors, Class A metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 32312978
- Full Text :
- https://doi.org/10.1038/s41467-020-15700-3