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Enriched environment and exercise effects on parvalbumin expression and distribution in the hippocampal formation of developing rats.

Authors :
Serra FT
Araujo BHS
Placencia EVD
Henrique JS
Dona F
Torres LB
Fernandes MJDS
Arida RM
Gomes da Silva S
Source :
Brain research bulletin [Brain Res Bull] 2020 Jul; Vol. 160, pp. 85-90. Date of Electronic Publication: 2020 Apr 17.
Publication Year :
2020

Abstract

Several models of environmental enrichment and physical exercise have been used to explore the experience effects on brain functions and plasticity, mainly in adult animals. In order to examine the early influence of these stimuli on developing brain, the present study used calcium-binding protein parvalbumin as neuroplastic marker in the hippocampal formation of male Wistar rats subjected to environmental enrichment or physical exercise from postnatal days 21 to 60 (P21-P60). In our study, no significant difference in hippocampal expression and distribution of parvalbumin was found between enriched and control rats. However, a significant increase in parvalbumin protein expression as well as in the number of neurons stained with parvalbumin was observed in the hippocampal formation of rats submitted to daily treadmill exercise when compared to the control rats. The hippocampal region with the highest number of parvalbumin neurons in exercised rats was Cornus of Amon 2 e 3 (CA2/CA3). These findings indicate that developing brain may be differentially sensitive to environmental stimulation models. Specifically, our results show that hippocampal expression and distribution of parvalbumin in developing rats may be more influenced by exercise than by enriched environment. The mechanisms are not yet known.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest. All authors read and approved the final manuscript.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)

Details

Language :
English
ISSN :
1873-2747
Volume :
160
Database :
MEDLINE
Journal :
Brain research bulletin
Publication Type :
Academic Journal
Accession number :
32305404
Full Text :
https://doi.org/10.1016/j.brainresbull.2020.03.021