Back to Search
Start Over
TNF-α pathway and T-cell immunity are activated early during the development of diabetic nephropathy in Type II Diabetes Mellitus.
- Source :
-
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Jun; Vol. 215, pp. 108423. Date of Electronic Publication: 2020 Apr 15. - Publication Year :
- 2020
-
Abstract
- Aim of the present study was to investigate the possible involvement of TNF-α signaling pathway and T-lymphocyte activation in DN. Eighty-two diabetic patients [39 male, age 69.5(56-78)years] were divided into three groups, according to Albumin/Creatinine ratio (ACR) levels, Group I (ACR < 30 μg/mg), Group II (ACR 30-300 μg/mg), Group III (ACR > 300 μg/mg). Urinary Tumor Necrosis Factor-α (TNF-α), and serum TNF-α, ΤNF-receptor 1 (TNFR1), TNFR2, B7-1, CD28, Cytoxic T-Lymphocyte-Associated protein-4 (CTLA4), were estimated. There were significant differences between Groups I, II, III regarding the concentration of urinary TNF-α (p < .001), serum TNFR1 (p < .001), serum TNFR2(p < .001), CTLA4 (p < .001) and CD28(p = .034). In multivariate analysis, independent parameters correlated with ACR were serum TNFR1 (p = .003), TNFR2 (p = .012) and urinary TNF-α (p = .015) levels. There was a significant correlation between markers of T-cell activation and TNF-α signaling pathway activation. Activation of TNF-α signaling pathway and T-lymphocytes seem to synergize and participate in the development of DN in type II DM.<br />Competing Interests: Declaration of Competing Interest The authors stated that they had no potential financial or other interests which might be perceived as posing a conflict or bias<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Biomarkers blood
Biomarkers urine
CTLA-4 Antigen immunology
Cross-Sectional Studies
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 urine
Diabetic Nephropathies blood
Diabetic Nephropathies urine
Female
Humans
Kidney immunology
Kidney metabolism
Male
Middle Aged
Receptors, Tumor Necrosis Factor, Type I blood
Receptors, Tumor Necrosis Factor, Type I immunology
Receptors, Tumor Necrosis Factor, Type I urine
Signal Transduction immunology
Tumor Necrosis Factor-alpha blood
Diabetes Mellitus, Type 2 immunology
Diabetic Nephropathies immunology
T-Lymphocytes immunology
Tumor Necrosis Factor-alpha immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1521-7035
- Volume :
- 215
- Database :
- MEDLINE
- Journal :
- Clinical immunology (Orlando, Fla.)
- Publication Type :
- Academic Journal
- Accession number :
- 32304735
- Full Text :
- https://doi.org/10.1016/j.clim.2020.108423