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Association of brachial-ankle pulse wave velocity and carotid plaque in Chinese hypertensive adults: effect modification by age.
- Source :
-
Hypertension research : official journal of the Japanese Society of Hypertension [Hypertens Res] 2020 Aug; Vol. 43 (8), pp. 808-816. Date of Electronic Publication: 2020 Apr 17. - Publication Year :
- 2020
-
Abstract
- We aimed to investigate the association of brachial-ankle pulse wave velocity (baPWV) with carotid plaque presence and carotid plaque number in a Chinese hypertensive population. A total of 13,554 hypertensive subjects from the China Stroke Primary Prevention Trial (CSPPT) were recruited. Arterial stiffness and carotid plaque were evaluated by baPWV and B-mode ultrasonography, respectively. Multivariate logistic regression analysis was used to determine the correlation of baPWV and carotid plaque presence. Multinomial logistic regression analysis was used to determine the correlation of baPWV and carotid plaque number. Further interactions between baPWV and carotid plaque presence were examined using subgroup analysis. Continuous baPWV was positively correlated with carotid plaque presence (OR = 1.05, 95% CI: 1.04-1.07) and carotid plaque number (one- to two-plaque group: OR = 1.04, 95% CI: 1.02-1.06; three-or-more-plaque group: OR = 1.09, 95% CI: 1.07-1.12). When baPWV was classified into quartiles, with the lowest quartile as reference, the ORs for having one, two, or three or more plaques increased in parallel with the quartiles of baPWV, indicating a dose-dependent effect. In a subgroup analysis, the association of baPWV and carotid plaque presence was more pronounced among younger participants (OR: 1.14 vs. 1.06 and 1.03 for the age groups <60 years, 60 ≤ 70 years, and ≥70 years, respectively, P for interaction <0.001). In a Chinese hypertensive population, baPWV was positively associated with carotid plaque presence and carotid plaque number. A more pronounced positive association between baPWV and carotid plaque presence was observed in younger participants.
- Subjects :
- Age Factors
Aged
Ankle Brachial Index
Brachial Artery physiopathology
Carotid Arteries diagnostic imaging
Carotid Artery Diseases diagnostic imaging
China
Female
Humans
Hypertension diagnostic imaging
Male
Middle Aged
Plaque, Atherosclerotic diagnostic imaging
Pulse Wave Analysis
Ultrasonography
Blood Pressure physiology
Carotid Arteries physiopathology
Carotid Artery Diseases physiopathology
Hypertension physiopathology
Plaque, Atherosclerotic physiopathology
Vascular Stiffness physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1348-4214
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Hypertension research : official journal of the Japanese Society of Hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 32303686
- Full Text :
- https://doi.org/10.1038/s41440-020-0432-2