E-cadherin deregulation in breast cancer.

Authors :: Corso G
Figueiredo J
De Angelis SP
Corso F
Girardi A
Pereira J
Seruca R
Bonanni B
Carneiro P
Pravettoni G
Guerini Rocco E
Veronesi P
Montagna G
Sacchini V
Gandini S
Source :: Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Jun; Vol. 24 (11), pp. 5930-5936. Date of Electronic Publication: 2020 Apr 16.
Publication Year :: 2020
Abstract: E-cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E-cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.<br /> (© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)