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Effects of coadministration of corn oil and ponazuril on serum and cerebrospinal fluid concentrations of ponazuril in horses.
- Source :
-
Journal of veterinary internal medicine [J Vet Intern Med] 2020 May; Vol. 34 (3), pp. 1321-1324. Date of Electronic Publication: 2020 Apr 17. - Publication Year :
- 2020
-
Abstract
- Background: Ponazuril is used for the treatment of equine protozoal myeloencephalitis (EPM). Coadministration of ponazuril with oil could result in higher serum and cerebrospinal fluid (CSF) concentrations of ponazuril.<br />Hypothesis: Coadministration of corn oil will result in higher serum and CSF concentrations of ponazuril than when ponazuril is administered alone.<br />Animals: Ten resident university-owned adult horses of either sex and >2 years of age.<br />Methods: Cohort study. Ponazuril oral paste (5 mg/kg BW; ponazuril treatment group (PON); n = 5), or ponazuril oral paste (5 mg/kg BW; ponazuril and oil treatment group (PONOIL; n = 5) coadministered with 2 oz of corn oil q24h for 21 days. Horses were treated once daily, for 21 days. Blood was collected on days 0, 7, 14, and 21 before dosing. In addition, CSF was collected on days 1, 7, 14, and 21. The concentration of ponazuril was determined in serum and CSF and results compared using repeated measures ANOVA.<br />Results: Coadministration of ponazuril with 2 oz of corn oil resulted in higher concentrations of ponazuril in serum (at steady state) than that found in horses given ponazuril alone (6.2 ± 0.9 mg/L versus 4.5 ± 1.0 mg/L; P = .004) (mean ± 1 SD). Cerebrospinal fluid concentrations of ponazuril were also greater in horses that received ponazuril and oil (0.213 mg/L ± 0.04 versus 0.162 ± 0.04 mg/L) (P = .03).<br />Conclusions and Clinical Importance: Results suggest that coadministration of corn oil with ponazuril might enhance the effectiveness of treatment with ponazuril.<br /> (© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)
- Subjects :
- Administration, Oral
Animals
Antiprotozoal Agents administration & dosage
Antiprotozoal Agents blood
Antiprotozoal Agents cerebrospinal fluid
Cohort Studies
Female
Horses
Male
Triazines blood
Triazines cerebrospinal fluid
Antiprotozoal Agents pharmacokinetics
Corn Oil administration & dosage
Triazines administration & dosage
Triazines pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1939-1676
- Volume :
- 34
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of veterinary internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32301131
- Full Text :
- https://doi.org/10.1111/jvim.15765