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Multiparametric Renal MRI: An Intrasubject Test-Retest Repeatability Study.
- Source :
-
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2021 Mar; Vol. 53 (3), pp. 859-873. Date of Electronic Publication: 2020 Apr 16. - Publication Year :
- 2021
-
Abstract
- Background: Renal multiparametric magnetic resonance imaging (MRI) is a promising tool for diagnosis, prognosis, and treatment monitoring in kidney disease.<br />Purpose: To determine intrasubject test-retest repeatability of renal MRI measurements.<br />Study Type: Prospective.<br />Population: Nineteen healthy subjects aged over 40 years.<br />Field Strength/sequences: T <subscript>1</subscript> and T <subscript>2</subscript> mapping, R <subscript>2</subscript> * mapping or blood oxygenation level-dependent (BOLD) MRI, diffusion tensor imaging (DTI), and intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI), 2D phase contrast, arterial spin labelling (ASL), dynamic contrast enhanced (DCE) MRI, and quantitative Dixon for fat quantification at 3T.<br />Assessment: Subjects were scanned twice with ~1 week between visits. Total scan time was ~1 hour. Postprocessing included motion correction, semiautomated segmentation of cortex and medulla, and fitting of the appropriate signal model.<br />Statistical Test: To assess the repeatability, a Bland-Altman analysis was performed and coefficients of variation (CoVs), repeatability coefficients, and intraclass correlation coefficients were calculated.<br />Results: CoVs for relaxometry (T <subscript>1</subscript> , T <subscript>2</subscript> , R <subscript>2</subscript> */BOLD) were below 6.1%, with the lowest CoVs for T <subscript>2</subscript> maps and highest for R <subscript>2</subscript> */BOLD. CoVs for all diffusion analyses were below 7.2%, except for perfusion fraction (F <subscript>P</subscript> ), with CoVs ranging from 18-24%. The CoV for renal sinus fat volume and percentage were both around 9%. Perfusion measurements were most repeatable with ASL (cortical perfusion only) and 2D phase contrast with CoVs of 10% and 13%, respectively. DCE perfusion had a CoV of 16%, while single kidney glomerular filtration rate (GFR) had a CoV of 13%. Repeatability coefficients (RCs) ranged from 7.7-87% (lowest/highest values for medullary mean diffusivity and cortical F <subscript>P</subscript> , respectively) and intraclass correlation coefficients (ICCs) ranged from -0.01 to 0.98 (lowest/highest values for cortical F <subscript>P</subscript> and renal sinus fat volume, respectively).<br />Data Conclusion: CoVs of most MRI measures of renal function and structure (with the exception of F <subscript>P</subscript> and perfusion as measured by DCE) were below 13%, which is comparable to standard clinical tests in nephrology.<br />Level of Evidence: 2 TECHNICAL EFFICACY: Stage 1.<br /> (© 2020 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine.)
- Subjects :
- Adult
Diffusion
Female
Glomerular Filtration Rate
Healthy Volunteers
Humans
Image Interpretation, Computer-Assisted methods
Image Processing, Computer-Assisted
Male
Middle Aged
Models, Statistical
Motion
Perfusion
Prognosis
Prospective Studies
Reproducibility of Results
Spin Labels
Kidney diagnostic imaging
Multiparametric Magnetic Resonance Imaging methods
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 53
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 32297700
- Full Text :
- https://doi.org/10.1002/jmri.27167