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Effects of stem cell transplantation in patients with peripheral T-cell lymphoma not otherwise specified and angioimmunoblastic T-cell lymphoma.
- Source :
-
International journal of hematology [Int J Hematol] 2020 Jul; Vol. 112 (1), pp. 74-83. Date of Electronic Publication: 2020 Apr 15. - Publication Year :
- 2020
-
Abstract
- The effects of stem cell transplantation (SCT) in patients with peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL) remain controversial. We analyzed the feasibility of SCT and risk factors associated with outcomes of PTCL-NOS and AITL patients to identify the potential clinical efficacy of SCT. We retrospectively analyzed the data of PTCL-NOS (n = 83) and AITL (n = 112) patients who received autologous (n = 10 and 16, respectively) or allogeneic (n = 12 and 4, respectively) SCT, or no SCT (n = 61 and 92, respectively) between 2008 and 2018. All PTCL-NOS and AITL diagnoses were reconfirmed by an experienced hematopathologist. Median age at PTCL-NOS and AITL diagnoses in the SCT group was younger than that in the no SCT group. Significant risk factors for lower overall survival were intermediate-high and high-risk international prognostic indexes in PTCL-NOS patients (P = 0.0052), and a > 2 modified prognostic index for T-cell lymphoma (P = 0.0079) and no SCT (P = 0.028) in AITL patients. Autologous or allogeneic SCT compared with no SCT in AITL patients resulted in 3-year overall survival of 68.6% and 100% vs. 57.2% (P = 0.018). Strategies should be developed to improve selection of PTCL-NOS and AITL patients suitable for SCT and/or additional novel therapies.
- Subjects :
- Adult
Aged
Aged, 80 and over
Feasibility Studies
Female
Humans
Immunoblastic Lymphadenopathy mortality
Lymphoma, T-Cell mortality
Lymphoma, T-Cell, Peripheral mortality
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Transplantation, Homologous
Treatment Outcome
Immunoblastic Lymphadenopathy therapy
Lymphoma, T-Cell therapy
Lymphoma, T-Cell, Peripheral therapy
Stem Cell Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 1865-3774
- Volume :
- 112
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of hematology
- Publication Type :
- Academic Journal
- Accession number :
- 32297159
- Full Text :
- https://doi.org/10.1007/s12185-020-02879-w