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Janus Face of Drug-Induced Tetraploidy in Non-Hodgkin Lymphoma.
- Source :
-
Trends in cancer [Trends Cancer] 2020 Aug; Vol. 6 (8), pp. 627-630. Date of Electronic Publication: 2020 Apr 11. - Publication Year :
- 2020
-
Abstract
- Anticancer agents often cause drug-induced tetraploidy (DIT) in cancer cells. DIT is not only a mechanism of inherited drug resistance, but proliferating DIT cells can produce progeny with increased ploidy or aneuploid genomes that drive aggressive disease. Here, we explore combinatorial therapeutic strategies for either preventing or eliminating DIT cells.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Antineoplastic Combined Chemotherapy Protocols therapeutic use
Chromosomal Instability drug effects
DNA Replication drug effects
Humans
Lymphoma, Non-Hodgkin genetics
Antineoplastic Combined Chemotherapy Protocols pharmacology
Chromosome Segregation drug effects
Lymphoma, Non-Hodgkin drug therapy
Tetraploidy
Subjects
Details
- Language :
- English
- ISSN :
- 2405-8025
- Volume :
- 6
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Trends in cancer
- Publication Type :
- Academic Journal
- Accession number :
- 32291237
- Full Text :
- https://doi.org/10.1016/j.trecan.2020.03.009