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Deep DNA metagenomic sequencing reveals oral microbiome divergence between monozygotic twins discordant for multiple sclerosis severity.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2020 Jun 15; Vol. 343, pp. 577237. Date of Electronic Publication: 2020 Apr 07. - Publication Year :
- 2020
-
Abstract
- In contrast to gut, the oral microbiome of MS patients has not been characterized. Deep sequencing of saliva DNA from a pair of monozygotic twins (MSF1 with relapsing remitting MS; MSF2 with clinically isolated syndrome) identified 2036 bacterial species. Relative abundances of 3 phyla were higher, and 3 lower in MSF1 versus MSF2. Species diversity was greater in MSF2, and 20 abundant species differed at least 2-fold. Pathway analysis identified 116 functional hierarchies differing 50% or more. Although limited to one pair of twins, our data suggests that oral microbiome analysis may be useful for diagnosis or monitoring therapeutic efficacy.<br />Competing Interests: Declaration of Competing Interest The authors declare they have no conflict of interest.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 343
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 32289594
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2020.577237