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Divergent Neural Pathways Emanating from the Lateral Parabrachial Nucleus Mediate Distinct Components of the Pain Response.
- Source :
-
Neuron [Neuron] 2020 Jun 17; Vol. 106 (6), pp. 927-939.e5. Date of Electronic Publication: 2020 Apr 13. - Publication Year :
- 2020
-
Abstract
- The lateral parabrachial nucleus (lPBN) is a major target of spinal projection neurons conveying nociceptive input into supraspinal structures. However, the functional role of distinct lPBN efferents in diverse nocifensive responses have remained largely uncharacterized. Here we show that that the lPBN is required for escape behaviors and aversive learning to noxious stimulation. In addition, we find that two populations of efferent neurons from different regions of the lPBN collateralize to distinct targets. Activation of efferent projections to the ventromedial hypothalamus (VMH) or lateral periaqueductal gray (lPAG) drives escape behaviors, whereas activation of lPBN efferents to the bed nucleus stria terminalis (BNST) or central amygdala (CEA) generates an aversive memory. Finally, we provide evidence that dynorphin-expressing neurons, which span cytoarchitecturally distinct domains of the lPBN, are required for aversive learning.<br />Competing Interests: Declaration of Interests The authors declare no competing interests.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Animals
Central Amygdaloid Nucleus physiology
Mice
Neural Pathways physiology
Neurons, Efferent physiology
Optogenetics
Pain
Periaqueductal Gray physiology
Septal Nuclei physiology
Ventromedial Hypothalamic Nucleus physiology
Avoidance Learning physiology
Escape Reaction physiology
Nociception physiology
Parabrachial Nucleus physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 106
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 32289251
- Full Text :
- https://doi.org/10.1016/j.neuron.2020.03.014