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Divergent Neural Pathways Emanating from the Lateral Parabrachial Nucleus Mediate Distinct Components of the Pain Response.

Authors :
Chiang MC
Nguyen EK
Canto-Bustos M
Papale AE
Oswald AM
Ross SE
Source :
Neuron [Neuron] 2020 Jun 17; Vol. 106 (6), pp. 927-939.e5. Date of Electronic Publication: 2020 Apr 13.
Publication Year :
2020

Abstract

The lateral parabrachial nucleus (lPBN) is a major target of spinal projection neurons conveying nociceptive input into supraspinal structures. However, the functional role of distinct lPBN efferents in diverse nocifensive responses have remained largely uncharacterized. Here we show that that the lPBN is required for escape behaviors and aversive learning to noxious stimulation. In addition, we find that two populations of efferent neurons from different regions of the lPBN collateralize to distinct targets. Activation of efferent projections to the ventromedial hypothalamus (VMH) or lateral periaqueductal gray (lPAG) drives escape behaviors, whereas activation of lPBN efferents to the bed nucleus stria terminalis (BNST) or central amygdala (CEA) generates an aversive memory. Finally, we provide evidence that dynorphin-expressing neurons, which span cytoarchitecturally distinct domains of the lPBN, are required for aversive learning.<br />Competing Interests: Declaration of Interests The authors declare no competing interests.<br /> (Copyright © 2020. Published by Elsevier Inc.)

Details

Language :
English
ISSN :
1097-4199
Volume :
106
Issue :
6
Database :
MEDLINE
Journal :
Neuron
Publication Type :
Academic Journal
Accession number :
32289251
Full Text :
https://doi.org/10.1016/j.neuron.2020.03.014