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A toxic palmitoylation of Cdc42 enhances NF-κB signaling and drives a severe autoinflammatory syndrome.
- Source :
-
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2020 Nov; Vol. 146 (5), pp. 1201-1204.e8. Date of Electronic Publication: 2020 Apr 10. - Publication Year :
- 2020
- Subjects :
- Actins metabolism
Guanine Nucleotide Dissociation Inhibitors metabolism
Humans
Infant
Lipoylation
Male
Pedigree
Protein Binding
Signal Transduction
Syndrome
Exome Sequencing
cdc42 GTP-Binding Protein genetics
Autoimmune Diseases genetics
Dermatitis, Exfoliative genetics
Inflammation genetics
Mutation genetics
NF-kappa B metabolism
Psoriasis genetics
cdc42 GTP-Binding Protein metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6825
- Volume :
- 146
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of allergy and clinical immunology
- Publication Type :
- Report
- Accession number :
- 32283203
- Full Text :
- https://doi.org/10.1016/j.jaci.2020.03.020