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[The effect of air pollution in diffuse interstitial lung disease].
- Source :
-
Revue des maladies respiratoires [Rev Mal Respir] 2020 May; Vol. 37 (5), pp. 389-398. Date of Electronic Publication: 2020 Apr 08. - Publication Year :
- 2020
-
Abstract
- Few studies have examined the effects of air pollution in diffuse interstitial lung disease and they have focused on small numbers of patients. Most data are available in idiopathic pulmonary fibrosis and studies suggest that the level of exposure to pollutants may influence the development of acute exacerbations (ozone and NO <subscript>2</subscript> ), their incidence (NO <subscript>2</subscript> ), decline in respiratory function (PM <subscript>10</subscript> ) and death (PM <subscript>10</subscript> and PM <subscript>2.5</subscript> ). Several studies show an increase in the incidence of rheumatoid arthritis in people living near busy roads. In systemic scleroderma, hypersensitivity pneumonitis and sarcoidosis although negative effects of pollution have been reported the data are insufficient to be conclusive. Nevertheless, the observed effects of air pollution are consistent with those described for other chronic respiratory diseases. Exposure to pollution induces oxidative stress, chronic inflammation and shortening of telomeres, which are all mechanisms described in fibrogenesis. New epidemiological studies are needed with individual measurements of exposure to outdoor and indoor pollution, as well as fundamental studies to clarify the effect of pollution on fibrogenesis.<br /> (Copyright © 2020. Published by Elsevier Masson SAS.)
- Subjects :
- Air Pollutants adverse effects
Air Pollutants toxicity
Air Pollution statistics & numerical data
Alveolitis, Extrinsic Allergic epidemiology
Alveolitis, Extrinsic Allergic etiology
Cardiovascular Diseases epidemiology
Cardiovascular Diseases etiology
Environmental Exposure adverse effects
Humans
Idiopathic Pulmonary Fibrosis epidemiology
Idiopathic Pulmonary Fibrosis etiology
Incidence
Lung Diseases, Interstitial epidemiology
Lung Diseases, Interstitial physiopathology
Ozone adverse effects
Particulate Matter adverse effects
Respiratory Physiological Phenomena drug effects
Risk Factors
Air Pollution adverse effects
Lung Diseases, Interstitial etiology
Subjects
Details
- Language :
- French
- ISSN :
- 1776-2588
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Revue des maladies respiratoires
- Publication Type :
- Academic Journal
- Accession number :
- 32278507
- Full Text :
- https://doi.org/10.1016/j.rmr.2020.02.015