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Triacylglycerol-Rich Oils of Marine Origin are Optimal Nutrients for Induction of Polyunsaturated Docosahexaenoic Acid Ester of Hydroxy Linoleic Acid (13-DHAHLA) with Anti-Inflammatory Properties in Mice.
- Source :
-
Molecular nutrition & food research [Mol Nutr Food Res] 2020 Jun; Vol. 64 (11), pp. e1901238. Date of Electronic Publication: 2020 Apr 22. - Publication Year :
- 2020
-
Abstract
- Scope: The docosahexaenoic acid ester of hydroxy linoleic acid (13-DHAHLA) is a bioactive lipid with anti-inflammatory properties from the family of fatty acid esters of hydroxy fatty acids (FAHFA).<br />Methods and Results: To explore the biosynthesis of 13-DHAHLA from dietary oils, C57BL/6N mice are gavaged for 8 days with various corn oil/marine oil mixtures containing the same amount of DHA. Plasma levels of omega-3 FAHFAs are influenced by the lipid composition of the mixtures but do not reflect the changes in bioavailability of polyunsaturated fatty acids in plasma. Triacylglycerol-bound DHA and linoleic acid serve as more effective precursors for 13-DHAHLA synthesis than DHA bound in phospholipids or wax esters. Both 13(S)- and 13(R)-DHAHLA inhibit antigen and PGE <subscript>2</subscript> -induced chemotaxis and degranulation of mast cells to a comparable extent and 13(S)-DHAHLA is identified as the predominant isomer in mouse adipose tissue.<br />Conclusion: Here, the optimal nutritional source of DHA is identified, which supports production of anti-inflammatory FAHFAs, as triacylglycerol-based marine oil and also reveals a possible role of triacylglycerols in the synthesis of FAHFA lipokines.<br /> (© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Anti-Inflammatory Agents, Non-Steroidal blood
Aquatic Organisms
Biological Availability
Chemotaxis drug effects
Fatty Acids, Omega-3 pharmacokinetics
Fatty Acids, Omega-3 pharmacology
Female
Linoleic Acids chemistry
Male
Mast Cells drug effects
Mice, Inbred C57BL
Stereoisomerism
Triglycerides chemistry
Anti-Inflammatory Agents, Non-Steroidal pharmacokinetics
Docosahexaenoic Acids pharmacokinetics
Oils chemistry
Oils pharmacokinetics
Subjects
Details
- Language :
- English
- ISSN :
- 1613-4133
- Volume :
- 64
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Molecular nutrition & food research
- Publication Type :
- Academic Journal
- Accession number :
- 32277573
- Full Text :
- https://doi.org/10.1002/mnfr.201901238