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TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
- Source :
-
Cancer discovery [Cancer Discov] 2020 Jun; Vol. 10 (6), pp. 779-782. Date of Electronic Publication: 2020 Apr 10. - Publication Year :
- 2020
-
Abstract
- TMPRSS2 is both the most frequently altered gene in primary prostate cancer and a critical factor enabling cellular infection by coronaviruses, including SARS-CoV-2. The modulation of its expression by sex steroids could contribute to the male predominance of severe infections, and given that TMPRSS2 has no known indispensable functions, and inhibitors are available, it is an appealing target for prevention or treatment of respiratory viral infections.<br /> (©2020 American Association for Cancer Research.)
- Subjects :
- COVID-19
Coronavirus Infections drug therapy
Coronavirus Infections mortality
Coronavirus Infections prevention & control
Esters
Female
Gabexate analogs & derivatives
Gabexate pharmacology
Gene Expression Regulation
Genetic Predisposition to Disease
Guanidines
Humans
Influenza, Human genetics
Male
Pandemics prevention & control
Pneumonia, Viral drug therapy
Pneumonia, Viral mortality
Pneumonia, Viral prevention & control
Prostatic Neoplasms genetics
Prostatic Neoplasms pathology
SARS-CoV-2
Betacoronavirus drug effects
Coronavirus Infections genetics
Pneumonia, Viral genetics
Serine Endopeptidases genetics
Serine Proteinase Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 2159-8290
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Cancer discovery
- Publication Type :
- Academic Journal
- Accession number :
- 32276929
- Full Text :
- https://doi.org/10.1158/2159-8290.CD-20-0451