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Multidrug-resistant patients receiving treatment in Niger who are infected with M. tuberculosis Cameroon family convert faster in smear and culture than those with M. tuberculosis Ghana family.
- Source :
-
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2020 May; Vol. 122, pp. 101922. Date of Electronic Publication: 2020 Mar 26. - Publication Year :
- 2020
-
Abstract
- In this study, we analyzed the M. tuberculosis complex (MTBc) population structure among multidrug-resistant TB (MDR-TB) patients in Niger and tested whether the Cameroon family displayed a slower response to MDR-TB treatment. We genotyped baseline clinical isolates that had been collected from pulmonary MDR-TB patients recruited consecutively between 2008 and 2016 in Niger. Spoligotyping was used to analyze the genetic diversity of mycobacterial lineages, and Kaplan Meier's analysis to compare treatment outcomes. A total of 222 MTBc isolates were genotyped; 204 (91,9%) were identified as the Euro-American L4 lineage, with the Ghana family (106, 47,4%) and the Cameroon family (63, 28,4%) being predominant. Patients infected by Cameroon family isolates 61(96,8%) showed faster conversion (log-rank p < 0.01) than those infected with Ghana family isolates (91,5%), and were more likely to experience favorable outcome (adjusted odds ratio [aOR] 4.4; 95%CI 1.1-17.9]; p = 0.015). We found no association between MTBc families and second-line drug resistance profiles (p > 0.05). Our findings show that MDR-TB in Niger is caused by major spoligotypes of the Euro-American L4; with more rapid smear and culture conversion in patients infected with the Cameroon family. These first insights may alert clinicians that slow conversion may be associated with the type of infecting strain.<br />Competing Interests: Declaration of competing interest The authors stated that they have no competing interests.<br /> (Copyright © 2020. Published by Elsevier Ltd.)
- Subjects :
- Bacteriological Techniques
Black People
Cameroon ethnology
Genotype
Ghana ethnology
Humans
Mycobacterium tuberculosis genetics
Mycobacterium tuberculosis pathogenicity
Niger epidemiology
Registries
Sputum microbiology
Time Factors
Treatment Outcome
Tuberculosis, Multidrug-Resistant diagnosis
Tuberculosis, Multidrug-Resistant ethnology
Tuberculosis, Multidrug-Resistant microbiology
Tuberculosis, Pulmonary diagnosis
Tuberculosis, Pulmonary ethnology
Tuberculosis, Pulmonary microbiology
Antitubercular Agents therapeutic use
Mycobacterium tuberculosis drug effects
Tuberculosis, Multidrug-Resistant drug therapy
Tuberculosis, Pulmonary drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1873-281X
- Volume :
- 122
- Database :
- MEDLINE
- Journal :
- Tuberculosis (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 32275231
- Full Text :
- https://doi.org/10.1016/j.tube.2020.101922