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MAP6 is an intraluminal protein that induces neuronal microtubules to coil.

Authors :
Cuveillier C
Delaroche J
Seggio M
Gory-Fauré S
Bosc C
Denarier E
Bacia M
Schoehn G
Mohrbach H
Kulić I
Andrieux A
Arnal I
Delphin C
Source :
Science advances [Sci Adv] 2020 Apr 01; Vol. 6 (14), pp. eaaz4344. Date of Electronic Publication: 2020 Apr 01 (Print Publication: 2020).
Publication Year :
2020

Abstract

Neuronal activities depend heavily on microtubules, which shape neuronal processes and transport myriad molecules within them. Although constantly remodeled through growth and shrinkage events, neuronal microtubules must be sufficiently stable to maintain nervous system wiring. This stability is somehow maintained by various microtubule-associated proteins (MAPs), but little is known about how these proteins work. Here, we show that MAP6, previously known to confer cold stability to microtubules, promotes growth. More unexpectedly, MAP6 localizes in the lumen of microtubules, induces the microtubules to coil into a left-handed helix, and forms apertures in the lattice, likely to relieve mechanical stress. These features have not been seen in microtubules before and could play roles in maintaining axonal width or providing flexibility in the face of compressive forces during development.<br /> (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)

Details

Language :
English
ISSN :
2375-2548
Volume :
6
Issue :
14
Database :
MEDLINE
Journal :
Science advances
Publication Type :
Academic Journal
Accession number :
32270043
Full Text :
https://doi.org/10.1126/sciadv.aaz4344