Mn-complex modified NaDyF 4 :Yb@NaLuF 4 :Yb,Er@polydopamine core-shell nanocomposites for multifunctional imaging-guided photothermal therapy.

Upconversion nanoparticles (UCNPs) have been used as building blocks in the construction of multimodal contrast agents for theranostics, that is, the combination of diagnostics and therapies. Upconversion luminescence (UCL) imaging is widely used for cell and tissue imaging while magnetic resonance imaging (MRI) is well-suited for in vivo imaging. Photothermal therapy (PTT) using (near-infrared) NIR laser radiation constitutes a minimally invasive alternative to the conventional surgical treatment of cancer. As such, multifunctional Mn-complex modified NaDyF ₄ :Yb@NaLuF ₄ :Yb,Er@polydopamine (PDA) nanocomposites (Dy@Lu@PDA-Mn) were synthesized, which was based on the fact that Yb ³⁺ and Er ³⁺ induce UCL, Dy ³⁺ and Mn ²⁺ interferes with T ₂ and T ₁ in MRI, and PDA strongly absorbs in the NIR region for PTT. Through tri-modal UCL, T ₁ -, T ₂ -weighted MRI guiding, an outstanding photothermal therapeutic efficacy with tumour elimination was obtained in a mice breast cancer model, by injection of Dy@Lu@PDA-Mn upon laser irradiation. A strategy for multimodal imaging-guided PTT was formulated and the potential of multifunctional nanostructures for use in cancer theranostics was demonstrated.