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Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.
- Source :
-
Journal of immunology research [J Immunol Res] 2020 Mar 16; Vol. 2020, pp. 2781350. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.<br />Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this article.<br /> (Copyright © 2020 Serena Vita et al.)
- Subjects :
- Adult
Aged
Female
Fibrosis
Hepatitis C, Chronic immunology
Humans
Immunity, Innate
Lymphocyte Activation
Male
Middle Aged
Antiviral Agents therapeutic use
Dendritic Cells immunology
Hepacivirus physiology
Hepatitis C, Chronic therapy
Immunotherapy methods
Interferon-alpha therapeutic use
Liver pathology
Monocytes immunology
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2314-7156
- Volume :
- 2020
- Database :
- MEDLINE
- Journal :
- Journal of immunology research
- Publication Type :
- Academic Journal
- Accession number :
- 32258171
- Full Text :
- https://doi.org/10.1155/2020/2781350