A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and enterotoxigenic Escherichia coli infections in mice.

Authors :: Medeiros PHQS
Bolick DT
Ledwaba SE
Kolling GL
Costa DVS
Oriá RB
Lima AÂM
Barry EM
Guerrant RL
Source :: NPJ vaccines [NPJ Vaccines] 2020 Mar 27; Vol. 5 (1), pp. 30. Date of Electronic Publication: 2020 Mar 27 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Vaccine studies for Shigella flexneri and enterotoxigenic Escherichia coli have been impaired by the lack of optimal animal models. We used two murine models to show that a S. flexneri 2a bivalent vaccine (CVD 1208S-122) expressing enterotoxigenic Escherichia coli colonization factor antigen-I (CFA/I) and the binding subunits A2 and B of heat labile-enterotoxin (LTb) is immunogenic and protects against weight loss and diarrhea. These findings document the immunogenicity and pre-clinical efficacy effects of CVD 1208S-122 vaccine and suggest that further work can help elucidate relevant immune responses and ultimately its clinical efficacy in humans.<br />Competing Interests: Competing interestsThe authors declare no competing interests.<br /> (© The Author(s) 2020.)

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