Phytochemical Study on Antioxidant and Antiproliferative Activities of Moroccan Caralluma europaea Extract and Its Bioactive Compound Classes.

Background: Caralluma europaea ( C . europaea ) is a medicinal plant used in Moroccan popular medicine. Objective of the Study . The present work was aimed at identifying the chemical composition and the antioxidant and antiproliferative activities of hydroethanolic and bioactive compound classes of C . europaea ) is a medicinal plant used in Moroccan popular medicine. Materials and Methods . The chemical composition was analyzed using HPLC. The antioxidant power was determined using both DPPH and FRAP assays. The antiproliferative activity was effectuated against cancerous cells using WST-1.
Results: The chemical analysis showed the presence of bioactive constituents such as quercetin, myricetin, and hesperetin. The polyphenol and flavonoid contents were estimated at 51.42 mg GA/g and 20.06 mg EQ/g, respectively. The EC ₅₀ values of FRAP assay of hydroethanolic, flavonoid, saponin, and mucilage extracts were 5.196 mg/ml, 4.537 mg/ml, 3.05 mg/ml, and 6.02 mg/ml, respectively. The obtained IC ₅₀ values with the DPPH test were 1.628 mg/ml, 1.05 mg/ml, 1.94 mg/ml, and 9.674 mg/ml, respectively. Regarding MDA-MB-231, saponins were highly effective even with the lowest concentration (15.62  μ g/ml). The flavonoids decreased the cell viability with IC ₅₀ values of 43.62 ± 0.06  μ g/ml). The flavonoids decreased the cell viability with IC ₅₀ values of 43.62 ± 0.06  μ g/ml). The flavonoids decreased the cell viability with IC ₅₀ values of 43.62 ± 0.06 .
Conclusion: The present results suggest that C . europaea ) is a medicinal plant used in Moroccan popular medicine.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2020 Fatima ez-zahra Amrati et al.)