Efficacy of Bedaquiline, Alone or in Combination with Imipenem, against Mycobacterium abscessus in C3HeB/FeJ Mice.

Authors :: Le Moigne V
Raynaud C
Moreau F
Dupont C
Nigou J
Neyrolles O
Kremer L
Herrmann JL
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 May 21; Vol. 64 (6). Date of Electronic Publication: 2020 May 21 (Print Publication: 2020).
Publication Year :: 2020
Abstract: Mycobacterium abscessus lung infections remain difficult to treat. Recent studies have recognized the power of new combinations of antibiotics, such as bedaquiline and imipenem, although in vitro data have questioned this combination. We report that the efficacy of bedaquiline-imipenem combination treatment relies essentially on the activity of bedaquiline in a C3HeB/FeJ mice model of infection with a rough variant of M. abscessus The addition of imipenem contributed to clearing the infection in the spleen.<br /> (Copyright © 2020 American Society for Microbiology.)

Subjects :: Animals
Anti-Bacterial Agents pharmacology
Diarylquinolines
Imipenem pharmacology
Mice
Microbial Sensitivity Tests
Mycobacterium Infections, Nontuberculous drug therapy
Mycobacterium abscessus

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