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Combination Therapy With Chemotherapy, Donor Lymphocyte Infusion With Concurrent Blinatumomab in Relapsed/Refractory Acute Precursor B-Lymphoblastic Leukemia.
- Source :
-
Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2021 Mar 01; Vol. 43 (2), pp. e280-e283. - Publication Year :
- 2021
-
Abstract
- The therapeutic approach for relapsed/refractory acute lymphoblastic leukemia (ALL) remains to be a challenge. The patient was diagnosed as B-cell ALL at 6 months of age and relapsed for the second time following repeat allogeneic hematopoietic stem cell transplantation (one after first complete remission [CR1] and the other after CR2). During blinatumomab monotherapy, he developed an extramedullary relapse. Finally, the combined therapy with clofarabine, donor lymphocyte infusion, and blinatumomab induced CR of the bone marrow and extramedullary relapse. Unfortunately, the patient developed central nervous system relapse, however, this case showed a promising potential for combination therapy with clofarabine, donor lymphocyte infusion, and blinatumomab in relapsed/refractory B-cell ALL.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Antibodies, Bispecific administration & dosage
Blood Donors
Clofarabine administration & dosage
Combined Modality Therapy
Cyclophosphamide administration & dosage
Cytarabine administration & dosage
Etoposide administration & dosage
Humans
Infant
Male
Neoplasm Recurrence, Local pathology
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma pathology
Prognosis
Retrospective Studies
Antineoplastic Combined Chemotherapy Protocols therapeutic use
Drug Resistance, Neoplasm
Lymphocyte Transfusion methods
Neoplasm Recurrence, Local therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1536-3678
- Volume :
- 43
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of pediatric hematology/oncology
- Publication Type :
- Academic Journal
- Accession number :
- 32251153
- Full Text :
- https://doi.org/10.1097/MPH.0000000000001789