Back to Search
Start Over
Intrauterine perfusion immunotherapies in recurrent implantation failures: Systematic review.
- Source :
-
American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2020 Jun; Vol. 83 (6), pp. e13242. Date of Electronic Publication: 2020 Apr 18. - Publication Year :
- 2020
-
Abstract
- Studies have investigated the gestational outcomes of new immunological therapies in the treatment of patients with recurrent implantation failure (RIF) in assisted reproductive technology (ART). The objective of this article is to assess the current state of evidence available in the literature on intrauterine perfusion immunotherapies in women undergoing ART treatments. By considering the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA), the authors performed systematic review by searching the databases of PubMed/MEDLINE and Scopus using the following key words: "recurrent implantation failure," "intrauterine infusion," "Platelet-Rich Plasma (PRP)," "Peripheral Blood Mononuclear Cells (PBMC)," "Granulocyte Colony-Stimulating Factor (G-CSF)," and "Human Chorionic Gonadotropin (hCG)." The authors analyzed the indications and the impact of new immunological therapies with intrauterine infusions on the pregnancy outcomes of patients undergoing ART. PRP, PBMC, G-CSF, and hCG were the four most used immunological therapies with intrauterine infusion. These new therapies appear to improve the results of ART treatments in cases of RIF. However, the small number of studies does not allow definitive conclusions about the effectiveness of these therapies.<br /> (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
- Subjects :
- Chorionic Gonadotropin metabolism
Embryo Implantation
Female
Granulocyte Colony-Stimulating Factor metabolism
Humans
Leukocytes, Mononuclear transplantation
Platelet-Rich Plasma
Pregnancy Complications immunology
Pregnancy Outcome
Blood Transfusion, Intrauterine methods
Immunotherapy methods
Leukocytes, Mononuclear immunology
Pregnancy
Pregnancy Complications therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0897
- Volume :
- 83
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- American journal of reproductive immunology (New York, N.Y. : 1989)
- Publication Type :
- Academic Journal
- Accession number :
- 32248580
- Full Text :
- https://doi.org/10.1111/aji.13242