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Hepatitis E virus outbreak associated with rainfall in the Central African Republic in 2008-2009.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2020 Apr 03; Vol. 20 (1), pp. 260. Date of Electronic Publication: 2020 Apr 03. - Publication Year :
- 2020
-
Abstract
- Background: Infection by hepatitis E virus (HEV) can cause a high burden of morbidity and mortality in countries with poor access to clean water and sanitation. Our study aimed to investigate the situation of HEV infections in the Central African Republic (CAR).<br />Methods: A retrospective analysis of the blood samples and notification forms collected through the national yellow fever (YF) surveillance program, but for which a diagnosis of YF was discarded, was carried out using an anti-HEV IgM ELISA and a HEV-specific RT-PCR.<br />Results: Of 2883 YF-negative samples collected between January 2008 and December 2012, 745 (~ 26%) tested positive by at least either of the 2 tests used to confirm HEV cases. The results revealed that the CAR was hit by a large HEV outbreak in 2008 and 2009. The results also showed a clear seasonal pattern with correlation between HEV incidence and rainfall in Bangui. A phylogenetic analysis showed that the circulating strains belonged to genotypes 1e and 2b.<br />Conclusions: Overall, this study provides further evidences that HEV can be a significant cause of acute febrile jaundice, particularly among adults during rainy season or flood, in a country from Sub-Saharan Africa.
- Subjects :
- Adolescent
Adult
Central African Republic epidemiology
Child
Enzyme-Linked Immunosorbent Assay
Female
Floods
Genotype
Hepatitis Antibodies blood
Hepatitis E complications
Hepatitis E virology
Hepatitis E virus isolation & purification
Humans
Immunoglobulin M blood
Incidence
Jaundice etiology
Longitudinal Studies
Male
Phylogeny
Real-Time Polymerase Chain Reaction
Retrospective Studies
Waterborne Diseases virology
Young Adult
Disease Outbreaks
Hepatitis E diagnosis
Hepatitis E epidemiology
Hepatitis E virus genetics
Hepatitis E virus immunology
Rain
Waterborne Diseases epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 32245368
- Full Text :
- https://doi.org/10.1186/s12879-020-04961-4