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Pre-Clinical Investigation of Keratose as an Excipient of Drug Coated Balloons.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 31; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 31. - Publication Year :
- 2020
-
Abstract
- Background: Drug-coated balloons (DCBs), which deliver anti-proliferative drugs with the aid of excipients, have emerged as a new endovascular therapy for the treatment of peripheral arterial disease. In this study, we evaluated the use of keratose (KOS) as a novel DCB-coating excipient to deliver and retain paclitaxel.<br />Methods: A custom coating method was developed to deposit KOS and paclitaxel on uncoated angioplasty balloons. The retention of the KOS-paclitaxel coating, in comparison to a commercially available DCB, was evaluated using a novel vascular-motion simulating ex vivo flow model at 1 h and 3 days. Additionally, the locoregional biological response of the KOS-paclitaxel coating was evaluated in a rabbit ilio-femoral injury model at 14 days.<br />Results: The KOS coating exhibited greater retention of the paclitaxel at 3 days under pulsatile conditions with vascular motion as compared to the commercially available DCB (14.89 ± 4.12 ng/mg vs. 0.60 ± 0.26 ng/mg, p = 0.018). Histological analysis of the KOS-paclitaxel-treated arteries demonstrated a significant reduction in neointimal thickness as compared to the uncoated balloons, KOS-only balloon and paclitaxel-only balloon.<br />Conclusions: The ability to enhance drug delivery and retention in targeted arterial segments can ultimately improve clinical peripheral endovascular outcomes.
- Subjects :
- Angioplasty, Balloon
Animals
Cardiovascular Agents administration & dosage
Drug Evaluation, Preclinical
Immunohistochemistry
Paclitaxel administration & dosage
Peripheral Arterial Disease drug therapy
Peripheral Arterial Disease etiology
Peripheral Arterial Disease metabolism
Peripheral Arterial Disease pathology
Antineoplastic Agents administration & dosage
Coated Materials, Biocompatible
Drug Carriers chemistry
Drug Delivery Systems
Keratosis
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 25
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 32244375
- Full Text :
- https://doi.org/10.3390/molecules25071596