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C-reactive protein levels in the early stage of COVID-19.
- Source :
-
Medecine et maladies infectieuses [Med Mal Infect] 2020 Jun; Vol. 50 (4), pp. 332-334. Date of Electronic Publication: 2020 Mar 31. - Publication Year :
- 2020
-
Abstract
- Background: COVID-19 is a new infectious disease, for which there is currently no treatment. It is therefore necessary to explore biomarkers to determine the extent of lung lesions and disease severity.<br />Objective: We aimed to assess the usefulness of CRP levels in the early stage of COVID-19 and to correlate them with lung lesions and severe presentation.<br />Methods: Confirmed cases of COVID-19 were selected at the Fever Unit in two regions of Guizhou, China. On admission CRP levels were collected, and the diameter of the largest lung lesion was measured in the most severe lung lesion by lung CT scan. Differences in the diameter and CRP levels were compared in the following groups of patients: mild group, moderate group, severe group, and critical group.<br />Result: CRP levels and the diameter of the largest lung lesion in the moderate group were higher than those in the mild group (Mann-Whitney test=-2.647, -2.171, P˂0.05), those in the severe group were higher than those in the moderate group (Mann-Whitney test=0.693, -2.177, P˂0.05), and those in the critical group were higher than those in the severe group (Mann-Whitney test=-0.068, -1.549, P˂0.05). The difference was statistically significant. CRP levels were positively correlated with the diameter of lung lesion and severe presentation (correlation coefficient=0.873, 0.734, P˂0.001).<br />Conclusion: In the early stage of COVID-19 CRP levels were positively correlated with lung lesions and could reflect disease severity.<br /> (Copyright © 2020 The Author. Published by Elsevier Masson SAS.. All rights reserved.)
- Subjects :
- Adolescent
Adult
Biomarkers blood
COVID-19
Child
Child, Preschool
China epidemiology
Coronavirus Infections epidemiology
Coronavirus Infections pathology
Critical Illness
Female
Humans
Infant
Lung Diseases diagnosis
Lung Diseases epidemiology
Male
Middle Aged
Pandemics
Pneumonia, Viral epidemiology
Pneumonia, Viral pathology
Time Factors
Tomography, X-Ray Computed
Young Adult
C-Reactive Protein analysis
Coronavirus Infections blood
Coronavirus Infections diagnosis
Disease Progression
Lung pathology
Lung Diseases blood
Lung Diseases pathology
Pneumonia, Viral blood
Pneumonia, Viral diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1769-6690
- Volume :
- 50
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Medecine et maladies infectieuses
- Publication Type :
- Academic Journal
- Accession number :
- 32243911
- Full Text :
- https://doi.org/10.1016/j.medmal.2020.03.007