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Feasibility, efficacy, and safety of cell-free and concentrated ascites reinfusion therapy (KM-CART) for malignant ascites.
- Source :
-
Artificial organs [Artif Organs] 2020 Oct; Vol. 44 (10), pp. 1090-1097. Date of Electronic Publication: 2020 Apr 20. - Publication Year :
- 2020
-
Abstract
- Efficacy for alleviating signs/symptoms of malignant ascites of a renovated CART (cell-free and concentrated ascites reinfusion therapy) system, called KM-CART, was evaluated. A total of 4781 KM-CART procedures were performed in 2109 patients. All patients were accepted unless hemodynamically unstable or consciousness impaired. The ascites were processed and drip-infused into the patient. There were no major complications or deaths. The mean drainage volume was 6.2 L (maximum: 27.7 L), patient symptoms (numerical scale system) were significantly alleviated (45.1 ± 19.0 reduced to 21.2 ± 14.2, P < .001), and patient leg circumference significantly decreased (33.3 ± 4.4 cm reduced to 30.5 ± 4.4 cm, P < .001) without exacerbation of renal function. Collected cancer cells could be utilized for immune therapy. KM-CART is capable of improving the "quality of best supportive care" and can be beneficial in conjunction with medication for alleviating malignant pain.<br /> (© 2020 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Ascites immunology
Combined Modality Therapy adverse effects
Combined Modality Therapy methods
Drainage adverse effects
Feasibility Studies
Female
Humans
Infusions, Parenteral adverse effects
Male
Middle Aged
Neoplasms complications
Neoplasms immunology
Treatment Outcome
Young Adult
Ascites therapy
Ascitic Fluid immunology
Drainage methods
Infusions, Parenteral methods
Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1594
- Volume :
- 44
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Artificial organs
- Publication Type :
- Academic Journal
- Accession number :
- 32242939
- Full Text :
- https://doi.org/10.1111/aor.13691