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Feasibility, efficacy, and safety of cell-free and concentrated ascites reinfusion therapy (KM-CART) for malignant ascites.

Authors :
Matsusaki K
Orihashi K
Source :
Artificial organs [Artif Organs] 2020 Oct; Vol. 44 (10), pp. 1090-1097. Date of Electronic Publication: 2020 Apr 20.
Publication Year :
2020

Abstract

Efficacy for alleviating signs/symptoms of malignant ascites of a renovated CART (cell-free and concentrated ascites reinfusion therapy) system, called KM-CART, was evaluated. A total of 4781 KM-CART procedures were performed in 2109 patients. All patients were accepted unless hemodynamically unstable or consciousness impaired. The ascites were processed and drip-infused into the patient. There were no major complications or deaths. The mean drainage volume was 6.2 L (maximum: 27.7 L), patient symptoms (numerical scale system) were significantly alleviated (45.1 ± 19.0 reduced to 21.2 ± 14.2, P < .001), and patient leg circumference significantly decreased (33.3 ± 4.4 cm reduced to 30.5 ± 4.4 cm, P < .001) without exacerbation of renal function. Collected cancer cells could be utilized for immune therapy. KM-CART is capable of improving the "quality of best supportive care" and can be beneficial in conjunction with medication for alleviating malignant pain.<br /> (© 2020 International Center for Artificial Organs and Transplantation and Wiley Periodicals, Inc.)

Details

Language :
English
ISSN :
1525-1594
Volume :
44
Issue :
10
Database :
MEDLINE
Journal :
Artificial organs
Publication Type :
Academic Journal
Accession number :
32242939
Full Text :
https://doi.org/10.1111/aor.13691