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Synthesis and Synthetic Application of Chloro- and Bromofuroxans.
- Source :
-
The Journal of organic chemistry [J Org Chem] 2020 May 01; Vol. 85 (9), pp. 5959-5972. Date of Electronic Publication: 2020 Apr 13. - Publication Year :
- 2020
-
Abstract
- Furoxans are potentially useful heteroaromatic units in pharmaceuticals and agrichemicals. However, the applications for furoxan-based compounds have been hampered due to the underdevelopment of their synthetic methods. Herein, we report a new synthetic approach for the synthesis of chloro- and bromofuroxans. The starting materials were dichloro- and dibromofuroxans, and the substituents were directly introduced to the furoxan ring in a modular fashion. The synthesized monohalofuroxans served as substrates for the installation of a second substituent to prepare further functionalized furoxans.
Details
- Language :
- English
- ISSN :
- 1520-6904
- Volume :
- 85
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- The Journal of organic chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 32242666
- Full Text :
- https://doi.org/10.1021/acs.joc.0c00326