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Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia.
- Source :
-
Journal of neural transmission (Vienna, Austria : 1996) [J Neural Transm (Vienna)] 2020 Apr; Vol. 127 (4), pp. 505-525. Date of Electronic Publication: 2020 Apr 02. - Publication Year :
- 2020
-
Abstract
- The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. These approaches have led to the discovery of several molecularly defined cell types that have been implicated in cutaneous mechanical allodynia, a highly prevalent and difficult-to-treat symptom of chronic pain, in which touch becomes painful. The main objective of this review is to provide a contemporary view of dorsal horn neuronal populations, and describe recent advances in our understanding of on how they participate in cutaneous mechanical allodynia.
- Subjects :
- Animals
Chronic Pain immunology
Chronic Pain metabolism
Chronic Pain physiopathology
Hyperalgesia immunology
Hyperalgesia metabolism
Hyperalgesia physiopathology
Inflammation immunology
Inflammation metabolism
Inflammation physiopathology
Neuralgia immunology
Neuralgia metabolism
Neuralgia physiopathology
Posterior Horn Cells classification
Posterior Horn Cells cytology
Posterior Horn Cells metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1435-1463
- Volume :
- 127
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of neural transmission (Vienna, Austria : 1996)
- Publication Type :
- Academic Journal
- Accession number :
- 32239353
- Full Text :
- https://doi.org/10.1007/s00702-020-02159-1