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Life, death, and autophagy in cancer: NF-κB turns up everywhere.
- Source :
-
Cell death & disease [Cell Death Dis] 2020 Mar 30; Vol. 11 (3), pp. 210. Date of Electronic Publication: 2020 Mar 30. - Publication Year :
- 2020
-
Abstract
- Escaping programmed cell death is a hallmark of cancer. NF-κB transcription factors are key regulator of cell survival and aberrant NF-κB signaling has been involved in the pathogenesis of most human malignancies. Although NF-κB is best known for its antiapoptotic role, other processes regulating the life/death balance, such as autophagy and necroptosis, seem to network with NF-κB. This review discusses how the reciprocal regulation of NF-κB, autophagy and programmed cell death affect cancer development and progression.
- Subjects :
- Autophagy
Humans
Signal Transduction
NF-kappa B metabolism
Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-4889
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cell death & disease
- Publication Type :
- Academic Journal
- Accession number :
- 32231206
- Full Text :
- https://doi.org/10.1038/s41419-020-2399-y