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[Emergence of 3D human fatty liver models engineered in the laboratory].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2020 Mar; Vol. 36 (3), pp. 261-263. Date of Electronic Publication: 2020 Mar 31. - Publication Year :
- 2020
-
Abstract
- Organoids offer an elegant approach to model human diseases and test new drugs. Nonalcoholic fatty liver disease (NAFLD) whose incidence has dramatically increased in recent years with the rise of obesity, is defined by triglyceride accumulation in hepatocytes, inflammation, liver injury, and progression to fibrosis. There is currently no approved therapy but many pathways are being explored. Two American teams have created mini-steatotic livers using different approaches, both using induced pluripotent stem cells (iPS), thus offering new tools to test developing drugs.<br /> (© 2020 médecine/sciences – Inserm.)
- Subjects :
- Animals
Bioengineering methods
Cells, Cultured
Disease Progression
Hepatocytes cytology
Hepatocytes pathology
Hepatocytes physiology
Humans
Liver pathology
Liver physiology
Liver Cirrhosis pathology
Medical Laboratory Science methods
Models, Biological
Tissue Culture Techniques methods
Tissue Scaffolds
Bioengineering trends
Medical Laboratory Science trends
Non-alcoholic Fatty Liver Disease pathology
Tissue Culture Techniques trends
Subjects
Details
- Language :
- French
- ISSN :
- 1958-5381
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 32228845
- Full Text :
- https://doi.org/10.1051/medsci/2020027