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Microvascular tissue as a platform technology to modify the local microenvironment and influence the healing cascade.
- Source :
-
Regenerative medicine [Regen Med] 2020 Feb; Vol. 15 (2), pp. 1313-1328. Date of Electronic Publication: 2020 Mar 31. - Publication Year :
- 2020
-
Abstract
- Aims: Profiling of microvascular tissue allows identification of components that stimulate wound healing. Here we study those elements for biological effect and establish clinical proof-of-concept using a microvascular tissue graft (mVASC <superscript>®</superscript> ) in chronic refractory wounds. Methods: mVASC was characterized for tissue fragments and protein composition, evaluated for angiogenic potential in preclinical models, and applied clinically to a series of nonhealing wounds with compromised vascularity of different etiologies. Results: mVASC increased endothelial cell migration in vitro and angiogenesis in mouse ingrowth and hindlimb ischemia models. Clinically, mVASC stimulated wound neovascularization, granulation and epithelialization, and complete and durable healing. Conclusion: Microvascular tissue contains elements relevant to tissue repair and can be clinically applied to enable or accelerate the closure of challenging wounds.
Details
- Language :
- English
- ISSN :
- 1746-076X
- Volume :
- 15
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Regenerative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 32228366
- Full Text :
- https://doi.org/10.2217/rme-2019-0139