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Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension.
- Source :
-
Emerging microbes & infections [Emerg Microbes Infect] 2020 Dec; Vol. 9 (1), pp. 757-760. - Publication Year :
- 2020
-
Abstract
- The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. COVID-19 patients with hypertension were enrolled to evaluate the effect of RAS inhibitors. We observed that patients receiving ACEI or ARB therapy had a lower rate of severe diseases and a trend toward a lower level of IL-6 in peripheral blood. In addition, ACEI or ARB therapy increased CD3 and CD8 T cell counts in peripheral blood and decreased the peak viral load compared to other antihypertensive drugs. This evidence supports the benefit of using ACEIs or ARBs to potentially contribute to the improvement of clinical outcomes of COVID-19 patients with hypertension.
- Subjects :
- Aged
Betacoronavirus
C-Reactive Protein analysis
CD3 Complex
CD8-Positive T-Lymphocytes cytology
COVID-19
China
Coronavirus Infections drug therapy
Female
Humans
Hypertension complications
Hypertension virology
Interleukin-6 blood
Male
Middle Aged
Pandemics
Pneumonia, Viral drug therapy
Retrospective Studies
SARS-CoV-2
Treatment Outcome
Viral Load
COVID-19 Drug Treatment
Angiotensin II Type 1 Receptor Blockers therapeutic use
Angiotensin-Converting Enzyme Inhibitors therapeutic use
Antihypertensive Agents therapeutic use
Coronavirus Infections complications
Hypertension drug therapy
Pneumonia, Viral complications
Renin-Angiotensin System
Subjects
Details
- Language :
- English
- ISSN :
- 2222-1751
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Emerging microbes & infections
- Publication Type :
- Editorial & Opinion
- Accession number :
- 32228222
- Full Text :
- https://doi.org/10.1080/22221751.2020.1746200